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. 2016 Apr 25;10:171. doi: 10.3389/fnins.2016.00171

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Copyright © 2016 Hakami, Hammad and Sari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of chronic ethanol consumption on GLT-1 isoforms (GLT-1a and GLT-1b) expression in NAc and PFC. (A) Statistical analysis showed significant downregulation of GLT-1a expression in ethanol vehicle group as compared to ethanol naïve (water) group in NAc. (B) Statistical analysis showed no significant difference of GLT-1a expression in PFC between ethanol naïve and ethanol vehicle groups. (C) Statistical analysis revealed significant downregulation of GLT-1b expression in ethanol vehicle group as compared to ethanol naïve group in NAc. (D) Statistical analysis also revealed no significant difference of GLT-1b expression in PFC between ethanol naïve and ethanol vehicle groups. Data are shown as mean ± SEM; (^*p < 0.05, ^**p < 0.01); (n = 5 for each group).