Table 2. Predictors of postoperative overall survival on 479 patients who underwent surgical resection for thymic epithelial tumors.
| Variables | Overall survival |
||||||
|---|---|---|---|---|---|---|---|
| Univariate |
Multivariate |
||||||
| OR | 95% CI | P value | OR | 95% CI | P value | ||
| Age | 1.043 | 1.023–1.064 | <0.001 | 1.047 | 1.026–1.069 | <0.001 | |
| Sex | |||||||
| Female | 1 | – | – | – | |||
| Male | 1.530 | 0.936–2.502 | 0.090 | ||||
| Presence of MG | |||||||
| No | 1 | ||||||
| Yes | 0.886 | 0.503–1.559 | 0.674 | ||||
| Preoperative treatment | |||||||
| None | 1 | ||||||
| CTx or RTx | 1.253 | 0.537–2.923 | 0.602 | ||||
| Surgical approach | 0.063 | – | – | – | |||
| Transsternal | 1 | ||||||
| VATS or robotic | 0.448 | 0.192–1.043 | |||||
| Surgical extent | 0.084 | – | – | – | |||
| Excision/thymecomy | 1 | ||||||
| Extended thymectomy | 0.581 | 0.314–1.076 | |||||
| Resection status | 0.019 | – | – | – | |||
| R0-resection | 1 | ||||||
| R1-resection | 2.154 | 1.237–3.749 | 0.007 | ||||
| R2-resection | 2.108 | 0.511–8.705 | 0.303 | ||||
| Masaoka-Koga stage | <0.001 | <0.001 | |||||
| Stage I | 1 | 1 | |||||
| Stage II | 1.389 | 0.734–2.628 | 0.313 | 1.454 | 0.768–2.751 | 0.250 | |
| Stage III | 2.216 | 1.235–3.974 | 0.008 | 1.998 | 1.112–3.591 | 0.021 | |
| Stage IV | 6.847 | 2.789–16.812 | 0.000 | 9.761 | 3.889–24.501 | <0.001 | |
| Maximal tumor diameter | 1.107 | 1.026–1.195 | 0.009 | – | – | – | |
| WHO classification | 0.326 | ||||||
| Type A or AB or B1 | 1 | ||||||
| Type B2 or B3 | 1.073 | 0.630–1.828 | 0.794 | ||||
| Type C | 1.681 | 0.845–3.346 | 0.139 | ||||
| Postoperative treatment | 0.204 | ||||||
| None | 1 | ||||||
| Radiation | 1.011 | 0.614–1.666 | 0.964 | ||||
| Chemotherapy | 3.615 | 1.096–11.924 | 0.035 | ||||
OR, odds ratio; CI, confidence interval; MG, myasthenia gravis; CTx, chemotherapy; RTx, radiation therapy; CRTx, chemoradiation therapy; VATS, video-assisted thoracoscopic surgery; WHO, World Health Organization.