Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of procathepsin B auto-activation in the presence of glycosaminoglycans (GAGs). GAG molecules bind to the occluding loop and the prodomain of cathepsin B molecule via electrostatic interactions. GAGs binding induce conformational change in procathepsin B (PDB ID: 1MIR), which unmasks the active site and enable the access of procathepsin B molecule.
