Table 2.
AUC for serum iron parameters after single i.v. doses of lexaptepid compared with baseline (means ± SD)
| Dose (mg·kg −1 ) | n | Serum iron AUC (μmol ·L −1 ·h −1 ) | TSAT AUC (%·h −1 ) | Serum ferritin AUC (μg ·L −1 ·h −1 ) |
|---|---|---|---|---|
| Placebo | 10 | 44.6 ± 28.4 | 62.5 ± 41.0 | 29.5 ± 45.3 |
| 0.3 | 6 | 47.6 ± 51.9 | 82.2 ± 76.9 | 15.5 ± 31.4 |
| 0.6 | 6 | 66.9 ± 40.3 | 111 ± 60.1 | 44.4 ± 53.2 |
| 1.2 | 6 | 193 ± 53.7 | 321 ± 137 | 125 ± 206 |
| 2.4 | 6 | 134 ± 45.0 | 239 ± 97.8 | 371 ± 291 |
| 4.8 | 6 | 225 ± 138 | 422 ± 334 | 644 ± 670 |
Area under the data–time curve above baseline from time 0 to 24 h after the last dose. TSAT, transferrin saturation.