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. 2016 Apr 5;173(10):1639–1652. doi: 10.1111/bph.13465

Figure 8.

Figure 8

Regulation of WT TASK‐2, TASK‐2_T108C and TASK‐2_T108P mutant channels by flufenamic acid (FFA). (A) Representative time course for enhancement of outward current by FFA (100 μM) for current through WT TASK‐2 channels. (B) Current–voltage relationships for WT TASK‐2 channels in the absence and presence of FFA (100 μM). (C) Representative time course for enhancement of outward current by FFA (100 μM) for current through TASK‐2_T108C mutant channels. (D) Current–voltage relationships for TASK‐2_T108C mutant channels in the absence and presence of FFA (100 μM). (E) Representative time course demonstrating lack of effect on the outward current by FFA (100 μM) on current through TASK‐2_T108P mutant channels. (F) Current–voltage relationships for TASK‐2_T108P mutant channels in the absence and presence of FFA (100 μM).