Table 2. Association of two SNPs with Behçet’s Disease.
Gene | SNP | Stage | Genotype/Allele | BD |
Controls |
P Value | Pc Value | OR (95% CI) | ||
---|---|---|---|---|---|---|---|---|---|---|
N | % | N | % | |||||||
ITGAX (CD11c) | rs2929 | First | AA | 15 | 3.8 | 23 | 3.8 | 0.986 | NS | 1.01 (0.52–1.95) |
AG | 82 | 21.0 | 193 | 32.0 | 1.453 × 10−4 | 0.019 | 0.56 (0.42–0.76) | |||
GG | 294 | 75.2 | 387 | 64.2 | 2.606 × 10−4 | 0.034 | 1.69 (1.27–2.25) | |||
G | 670 | 85.7 | 967 | 80.2 | 0.002 | NS | 1.48 (1.16–1.89) | |||
Second | AA | 12 | 1.6 | 40 | 2.7 | 0.107 | NS | 0.59 (0.31–1.13) | ||
AG | 180 | 23.7 | 470 | 31.3 | 1.974 × 10−4 | 1.184 × 10−3 | 0.69 (0.56–0.84) | |||
GG | 566 | 74.7 | 994 | 66.1 | 3.135 × 10−5 | 1.881 × 10−4 | 1.51 (1.24–1.84) | |||
G | 1312 | 86.5 | 2458 | 81.7 | 3.904 × 10−5 | 7.808 × 10−5 | 1.44 (1.21–1.71) | |||
Combined | AA | 27 | 2.3 | 63 | 3.0 | 0.287 | NS | 0.78 (0.50–1.23) | ||
AG | 262 | 22.8 | 663 | 31.5 | 1.618 × 10−7 | 2.087 × 10−5 | 0.64 (0.55–0.76) | |||
GG | 860 | 74.8 | 1381 | 65.5 | 4.320 × 10−8 | 5.573 × 10−6 | 1.56 (1.33–1.84) | |||
G | 1982 | 86.2 | 3425 | 81.3 | 3.252 × 10−7 | 1.398 × 10−5 | 1.45 (1.25–1.67) | |||
CD6 | rs11230563 | First | CC | 252 | 64.5 | 468 | 77.6 | 5.721 × 10−6 | 7.380 × 10−4 | 0.52 (0.39–0.69) |
CT | 128 | 32.7 | 121 | 20.1 | 6.685 × 10−6 | 8.624 × 10−4 | 1.94 (1.45–2.59) | |||
TT | 11 | 2.8 | 14 | 2.3 | 0.629 | NS | 1.22 (0.55–2.71) | |||
C | 632 | 80.8 | 1057 | 87.6 | 3.189 × 10−5 | 1.371 × 10−3 | 0.59 (0.46–0.76) | |||
Second | CC | 501 | 66.1 | 1137 | 75.6 | 1.811 × 10−6 | 1.087 × 10−5 | 0.63 (0.52–0.76) | ||
CT | 238 | 31.4 | 349 | 23.2 | 2.714 × 10−5 | 1.628 × 10−4 | 1.52 (1.25–1.84) | |||
TT | 19 | 2.5 | 18 | 1.2 | 0.020 | NS | 2.12 (1.11–4.07) | |||
C | 1240 | 81.8 | 2623 | 87.2 | 1.176 × 10−6 | 2.352 × 10−5 | 0.66 (0.56–0.78) | |||
combined | CC | 753 | 65.5 | 1605 | 76.2 | 8.501 × 10−11 | 1.097 × 10−8 | 0.60 (0.51–0.70) | ||
CT | 366 | 31.9 | 470 | 22.3 | 2.532 × 10−9 | 3.266 × 10−7 | 1.63 (1.39–1.91) | |||
TT | 30 | 2.6 | 32 | 1.5 | 0.029 | NS | 1.74 (1.05–2.88) | |||
C | 1872 | 81.5 | 3680 | 87.3 | 1.766 × 10−10 | 7.594 × 10−9 | 0.64 (0.56–0.73) |
Pc, Bonferroni corrected p value; NS, not significant; SNP, single nucleotide polymorphism.