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. 2016 Apr 25;6:24949. doi: 10.1038/srep24949

Figure 1. Schematic overview of the multi-omic approach.

Figure 1

The seven principal steps in MEREDITH to process and integrate genome-wide data of the four molecular data-types (GE, ME, CN, and MIR). Step 1. Mapping of features to the corresponding genes, 2. PCA per platform for an initial dimensionality reduction, 3. The retained the 50 PCs with the highest eigenvalues for each data set, 4. PC scaling, 5. Concatenation of the PCs per data set, 6. Mapping to a two-dimensional multiplatform map using t-distributed stochastic neighborhood embedding, 7. Cluster analysis, analysis of the contribution of different molecular types, and survival analysis can subsequently be applied.