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. 2016 Apr 25;6:24949. doi: 10.1038/srep24949

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Kaplan-Meier survival plot depicted the overall survival (OS) for the COP-I, COP-II and all other remaining samples. The P-value describes the comparison between COP-II samples versus all other samples using the log-rank statistics. (b) Cox proportional hazard ratio regression model to determine associations with OS for COP-I and COP-II samples groups after correcting for covariates. The covariates are chosen based on the cancer-tissues that were seen among the COP samples. (c) Significantly enriched pathways for the COP-II sample group. (d) Co-expression network based on gene expression profiles for the COP-II sample group. Node size depicts the −log10(P-value) for differential expression between COP-II sample group and all other remaining samples. Node color depicts either significant upregulation (red), downregulation (blue), DNA-methylation (green), or copy-number changes (purple). Edges with positive correlation are depicted in red, whereas negative correlations are depicted in blue. Co-expression network is clustered in four distinct groups and significantly enriched pathways for each cluster are depicted.