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. 2016 Apr 25;6:24714. doi: 10.1038/srep24714

Figure 2. Bk–induced vasodilation responses in the coronary circulation of isolated heart in female ApoE/LDLR−/− mice.

Figure 2

(A–C) Preservation of coronary flow responses evoked by Bk in the isolated hearts of 2, 4 and 8-month old ApoE/LDLR−/− mice compared with age-matched C57BL6/J mice; n = 11 for 2-month old C57BL6/J mice, n = 13 for 2-month old ApoE/LDLR−/− mice, n = 14 for 4-month old C57BL6/J mice and n = 10 for 4-month old ApoE/LDLR−/− mice, n = 9 for 8-month old C57BL6/J mice and n = 18 for 8-month old ApoE/LDLR−/− mice. (D–F) NO-dependent part of coronary flow responses evoked by Bk in the isolated heart of ApoE/LDLR−/− mice compared with controls subjected to L-NAME (500 μM) treatment; n = 6 for 2-month old C57BL6/J mice, n = 6 for 2-month old ApoE/LDLR−/− mice, n = 7 for 4-month old C57BL6/J mice and n = 8 for 4-month old ApoE/LDLR−/− mice, n = 5 for 8-month old C57BL6/J mice and n = 8 for 8-month old ApoE/LDLR−/− mice. Statistical analysis was performed using t-test or non-parametric Mann-Whitney test, when assumptions were not completed. Data are presented as the mean ± SEM.