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. 2016 Apr 25;6:24714. doi: 10.1038/srep24714

Figure 3. SNAP and SNP–induced vasodilation responses in the coronary circulation of isolated heart in female ApoE/LDLR−/− mice.

Figure 3

(A–C) Up-regulation of SNAP-induced coronary flow response in the isolated hearts of in 2, 4 and 8-month old ApoE/LDLR−/− mice compared with age-matched C57BL6/J mice; n = 12 for 2-month old C57BL6/J mice, n = 7 for 2-month old ApoE/LDLR−/− mice, n = 6 for 4-month old C57BL6/J mice and n = 9 for 4-month old ApoE/LDLR−/− mice, n = 7 for 8-month old C57BL6/J mice and n = 13 for 8-month old ApoE/LDLR−/− mice. (D–F) SNP-induced coronary flow response in isolated hearts from ApoE/LDLR−/− mice compared with age-matched C57BL6/J mice; n = 7 for 2-month old C57BL6/J mice, n = 14 for 2-month old ApoE/LDLR−/− mice, n = 5 for 4-month old C57BL6/J mice and n = 14 for 4-month old ApoE/LDLR−/− mice, n = 10 for 8-month old C57BL6/J mice and n = 15 for 8-month old ApoE/LDLR−/− mice. Statistical analysis was performed using t-test or non-parametric Mann-Whitney test, when assumptions were not completed. Data are presented as the mean ± SEM.