Figure 6. Cardiac reserve for low (0.5 mg^·kg⁻¹) and high (2.0 mg^·kg⁻¹) dose of dobutamine in female ApoE/LDLR^−/− mice.

Dobutamine stress test uncovered well-preserved cardiac reserve in ApoE/LDLR^−/− mice. *indicates statistical significance in comparison of the ApoE/LDLR^−/− and the control mice at basal conditions (P < 0.05, t-test; n = 7 in each group), whereas changes after dobutamine were marked as + for comparisons between the given dose of dobutamine (low or high) and the basal condition, and as # for comparisons between the high and low dose (P < 0.05, ANOVA and Tukey post-hoc test); n = 7–8 for C57BL6/J mice and 6 for ApoE/LDLR^−/− mice. Data are presented as the mean ± SEM.