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. 2016 Apr 25;6:24912. doi: 10.1038/srep24912

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Schematic illustration of brain tumor-favorable microenvironment. Hyaluronic acid (HA)-rich extracellular matrix (ECM) and pre-existing brain anatomy (e.g. white matter tract). (B) Illustration of three major components in HA metabolism. Transcriptomic analysis of Gene Expression Omnibus (GEO) data for three major HA metabolic genes between normal brain tissue and GBM tissue: HA receptors (CD44, RHAMM), HA Synthases (HAS1, HAS2, and HAS3), and Hyaluronidase (HYAL1, HYAL2, HYAL3, and HYAL4). The normalized gene expression ranging from 0 (no expression) and 1 (fully expression). Red bar indicates the statistical significance between normal and GBM tissue.