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. 2016 Apr 20;7:11349. doi: 10.1038/ncomms11349

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(a) Scheme of mammalian cerebral development. Before onset of neurogenesis, APs (apical progenitor cells, neuroepithelial cells (NEs) at this stage) undergo proliferative symmetric division. After onset of neurogenesis, APs overtime undergo temporal progression with respect to two properties: division mode (proliferative versus neurogenic) and the fates of their differentiating progeny (deep-layer neurons versus upper-layer neurons). A, anterior; P, posterior; D, dorsal; V, ventral; IP, intermediate progenitor cell. (b–e) E14-based hierarchical clustering analysis of single-cell cDNA classifies E11- and E16-derived cortical progenitor cells. Clustering dendrograms show the results from the SigABC genes. In the dendrograms, each label represents a single cell, and the label colour indicates the cluster where it belongs. The values in red at the branches are AU (approximately unbiased) P values (%). The horizontal branch length represents the degree of dissimilarity in gene expression among the samples. See also Supplementary Figs 1–4.