Table 1. Decomposition of G1 variability.
G1 noise for λTG1 | Noise due to size control | Size-independent noise | |
---|---|---|---|
WT (exp) | 0.55 | 0.31 (32%) | 0.45 (68%) |
WT (sim) | 0.52 | 0.23 (19%) | 0.47 (81%) |
6 × Cln3 (exp) | 0.44 | 0.25 (32%) | 0.36 (68%) |
6 × Cln3 (sim) | 0.33 | 0.13 (15%) | 0.31 (85%) |
6 × Cln2 (exp) | 0.48 | 0.30 (39%) | 0.37 (61%) |
6 × Cln2 (sim) | 0.43 | 0.25 (35%) | 0.34 (65%) |
6 × Cln3, 6 × Cln2 (exp) | 0.37 | 0.18 (24%) | 0.32 (76%) |
6 × Cln3, 6 × Cln2 (sim) | 0.40 | 0.10 (6%) | 0.39 (94%) |
WT, wild type.
Decomposition of G1 variability in terms of deterministic size control and a residual that is attributable to molecular noise under the assumption that λTG1 can be decomposed into the sum of a suitable deterministic function of the initial protein content f(P(0)) plus a stochastic variable. The chosen function for f(P(0)) is the hyperbola described in Fig. 3e. The experimental data are from ref. 13.