Table 1.

Treatment Regimens for Genotype 1a and 1b Hepatitis C Virus Infection^31,32

Genotype 1a
Treatment Naive
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID + WB ribavirin 1000/1200 mg	12 weeks
Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin 1000/1200 mg	12 weeks
Treatment Naive + Cirrhosis
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID + WB ribavirin 1000/1200 mg	24 weeks
Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin 1000/1200 mg	24 weeks
Treatment Failure: PEG-IFN and Ribavirin
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID + WB ribavirin 1000/1200 mg	12 weeks
Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin 1000/1200 mg	12 weeks
Treatment Failure: Sofosbuvir
Without advanced fibrosis: defer treatment
Treatment Failure: PEG-IFN, Ribavirin, PI
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Treatment Failure: PEG-IFN and Ribavirin + Cirrhosis
Ledipasvir 90 mg/sofosbuvir 400 mg daily	24 weeks
Ledipasvir 90 mg/sofosbuvir 400 mg daily + WB ribavirin 1000/1200 mg	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID + WB ribavirin 1000/1200 mg	24 weeks
Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin 1000/1200 mg	24 weeks
Treatment Failure: Sofosbuvir + Cirrhosis
Advanced fibrosis: ledipasvir 90 mg/sofosbuvir 400 mg daily ± WB ribavirin 1000/1200 mg	24 weeks
Treatment Failure: PEG-IFN, Ribavirin, PI + Cirrhosis
Ledipasvir 90 mg/sofosbuvir 400 mg daily	24 weeks
Ledipasvir 90 mg/sofosbuvir 400 mg daily + WB ribavirin 1000/1200 mg	12 weeks
Genotype 1b
Treatment Naive
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID	12 weeks
Sofosbuvir 400 mg + simeprevir 150 mg	12 weeks
Treatment Naive + Cirrhosis
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID + WB ribavirin 1000/1200 mg	12 weeks
Sofosbuvir 400 mg + simeprevir 150 mg	24 weeks
Treatment Failure: PEG-IFN and Ribavirin
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID	12 weeks
Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin 1000/1200 mg	12 weeks
Treatment Failure: Sofosbuvir
Without advanced fibrosis: defer treatment
Treatment Failure: PEG-IFN, Ribavirin, PI
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Treatment Failure: PEG-IFN and Ribavirin + Cirrhosis
Ledipasvir 90 mg/sofosbuvir 400 mg daily	24 weeks
Ledipasvir 90 mg/sofosbuvir 400 mg daily + WB ribavirin 1000/1200 mg	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID + WB ribavirin 1000/1200 mg	12 weeks
Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin 1000/1200 mg	24 weeks
Treatment Failure: Sofosbuvir + Cirrhosis
Advanced fibrosis: ledipasvir 90 mg/sofosbuvir 400 mg daily ± WB ribavirin 1000/1200 mg	24 weeks
Treatment Failure: PEG-IFN, Ribavirin, PI + Cirrhosis
Ledipasvir 90 mg/sofosbuvir 400 mg daily	24 weeks
Ledipasvir 90 mg/sofosbuvir 400 mg daily + WB ribavirin 1000/1200 mg	12 weeks

PEG-IFN, pegylated interferon; PI, protease inhibitor; WB, weight-based. WB ribavirin: <75 kg=1000 mg, ≥75 kg=1200 mg.