Table 2.

Treatment Regimens for Genotypes 2, 3, 4, 5, and 6 Hepatitis C Virus Infection^31,32

Genotype 2
Treatment Naive
Sofosbuvir 400 mg + WB ribavirin daily	12 weeks
Treatment Naive + Cirrhosis
Sofosbuvir 400 mg + WB ribavirin daily	16 weeks
Treatment Failure: PEG-IFN and Ribavirin
Sofosbuvir 400 mg + WB ribavirin daily	12-16 weeks
(Alternative) Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks
Genotype 3
Treatment Naive
Sofosbuvir 400 mg + WB ribavirin daily	24 weeks
(Alternative) Sofosbuvir 400 mg + WB ribavirin daily for 24 weeks + PEG-IFN weekly for 12 weeks	24/12 weeks
Treatment Failure: PEG-IFN and Ribavirin
Sofosbuvir 400 mg + WB ribavirin daily	24 weeks
(Alternative) Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks
Genotype 4
Treatment Naive
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + WB ribavirin 1000/1200 mg	12 weeks
Sofosbuvir 400 mg + WB ribavirin daily	24 weeks
(Alternative) Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks
(Alternative) Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin	12 weeks
Treatment Failure: PEG-IFN and Ribavirin
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + WB ribavirin 1000/1200 mg	12 weeks
Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks
Sofosbuvir 400 mg + WB ribavirin daily	24 weeks
Genotype 5
Treatment Naive
Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks
WB ribavirin daily + PEG-IFN weekly	48 weeks
Treatment Failure
Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks
(Alternative) PEG-IFN weekly + WB ribavirin daily	48 weeks
Genotype 6
Treatment Naive
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
(Alternative) Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks
Treatment Failure
Ledipasvir 90 mg/sofosbuvir 400 mg daily	12 weeks
(Alternative) Sofosbuvir 400 mg + WB ribavirin daily + PEG-IFN weekly	12 weeks

PEG-IFN, pegylated interferon; WB, weight-based. WB ribavirin: <75 kg=1000 mg, ≥75 kg=1200 mg.