. 2015 Jul;11(7):458–466.

Table 3.

Treatment Regimens for Special Populations With Hepatitis C Virus Infection³¹^,³²

HCV/HIV Coinfection^a
*Ledipasvir 90 mg/Sofosbuvir 400 mg Daily*
Avoid with tenofovir/ritonavir combination, cobicistat, elvitegravir, tipranavir
*Paritaprevir 150 mg/Ritonavir 100 mg/Ombitasvir 25 mg Daily + Dasabuvir 250 mg BID*
Use with raltegravir, enfuvirtide, tenofovir, emtricitabine, lamivudine, atazanavir
Avoid with efavirenz, rilpivirine, darunavir, ritonavir-boosted lopinavir
Must be on antiretroviral therapy
*Simeprevir*
Avoid with efavirenz, etravirine, nevirapine, cobicistat, HIV protease inhibitors
*Ribavirin*
Avoid with didanosine, stavudine, zidovudine
Decompensated Cirrhosis
*Genotype 1, 4; Treatment Naive*
Ledipasvir 90 mg/sofosbuvir 400 mg daily + ribavirin 600 mg (increase as tolerated)	12 weeks
*Genotype 1, 4; Anemia/Ribavirin Intolerant*
Ledipasvir 90 mg/sofosbuvir 400 mg daily	24 weeks
*Genotype 1, 4; Treatment Failure: Sofosbuvir*
Ledipasvir 90 mg/sofosbuvir 400 mg daily + ribavirin 600 mg (increase as tolerated)	24 weeks
*Genotype 2,3; Treatment Naive*
Sofosbuvir 400 mg + WB ribavirin daily	up to 48 weeks
Posttransplant
*Genotype 1, 4; Including Compensated Cirrhosis; Treatment Naive and Failure*
Ledipasvir 90 mg/sofosbuvir 400 mg daily + WB ribavirin 1000/1200 mg	12 weeks
(Alternative) Ledipasvir 90 mg/sofosbuvir 400 mg daily	24 weeks
*Genotype 1; Including Compensated Cirrhosis but Without Cirrhosis*
Sofosbuvir 400 mg + simeprevir 150 mg ± WB ribavirin	12 weeks
(Alternative) Paritaprevir 150 mg/ritonavir 100 mg/ombitasvir 25 mg daily + dasabuvir 250 mg BID + WB ribavirin 1000/1200 mg	24 weeks
*Genotype 2; Treatment Naive and Failure*
Sofosbuvir 400 mg + WB ribavirin daily	24 weeks
*Genotype 3; Treatment Naive and Failure*
Sofosbuvir 400 mg + WB ribavirin daily	24 weeks
*Genotype 3; Decompensated Cirrhosis*
Sofosbuvir 400 mg + ribavirin 600 mg (increase as tolerated)	24 weeks
Pretransplant
Unclear
Retreatment of Sofosbuvir Failure
Unclear

WB, weight-based. WB ribavirin: <75 kg=1000 mg, ≥75 kg=1200 mg.

Otherwise treat these patients the same as those without HIV infection.