The location of the en face OCT shown in (D) is outlined on the fundus photograph (A). In this subject a large elliptical EZ disruption with a central core of low reflectivity is visualized with en face OCT (D). Dashed lines on D indicate locations of the horizontal and vertical B-scans (B,C), while the square represents the area shown in (E–G). The confocal AOSLO image revealed ambiguous reflectivity from the present photoreceptors (F). The split-detector image revealed that the central core of the disruption contains dramatically enlarged (likely cone) photoreceptor inner segments, surrounded by smaller diameter (likely rod) photoreceptors indicated by “*” (G). The darkest area of the en face image (E) contains few scattered enlarged inner segments, visible in the split-detector image (G, arrows). The corresponding locations in the confocal image (F) are marked with open arrows. B–D scalebars = 200 μm. E–G scalebars = 100 μm.