The location of the en face OCT shown in (D) is outlined on the fundus photograph (A). The en face OCT revealed a clover leaf shaped EZ disruption centered at the macula (D). Dashed lines on D indicate locations of the horizontal and vertical B-scans (B,C), while the square represents the area shown in (E–G). Within the EZ disruption there are two distinct levels of reduced reflectivity, the center of the disruption shows nearly no reflectivity, while there is a bordering region that reflects at a level between the center and the normal EZ outside (E). The confocal AOSLO imaging revealed waveguiding photoreceptors only in the regions of normal EZ reflectivity (F). The split-detector image on the other hand revealed photoreceptors in the border zone of abnormal EZ reflectivity, as well as photoreceptors within the EZ disruption (G). B–D scalebars = 200 μm. E–G scalebars = 100 μm.