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Reduced binding to MBD proteins is shown in 5hmC/5mCpGs compared with 5mC/5mCpGs. (A) Binding of 5mC/5mCpGs and 5hmC/5mCpGs containing DNA to varying concentrations of the methyl-CpG binding domain of human MBD2 protein assayed via EMSA. (B) Model for potential function of 5hmC/5mCpGs in promoting gene expression.
