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. Author manuscript; available in PMC: 2016 Aug 27.
Published in final edited form as: Cell. 2015 Aug 27;162(5):961–973. doi: 10.1016/j.cell.2015.07.056

Figure 7. RIG1 or MDA5 agonists reduce the frequency of primary colorectal CICs independent of CIMP status.

Figure 7

Frequency of colorectal CICs before and after transfection with 0.5 ug/ml of low molecular weight (LMW – RIG1 agonist) or high molecular weight (HMW – MDA5 agonist) poly(I:C) measured by in-vitro limiting dilution assay. Patient-derived cells obtained from a CIMPhigh (sample 92) (A), a CIMPlow (sample 181) (B), and a non-CIMP (sample 73) (C) were used. The y-axis denotes the confidence intervals (lower, estimate and upper) for CIC frequency. Pairwise chi-squared test was used to test for difference in CIC frequency. See also Figure S7.