Figure 2.

Site validation and annotation steps in the updated CollecTF curation pipeline. (a) Validation of the genome mapping process for individual sites, following sequence search or coordinate entry. Curators make use of the genetic neighborhood for each site to validate the mapping process and determine the proper mapping when a reported sequence maps to multiple genome locations. (b) In the updated pipeline, submitters can annotate independently each reported site in a single curation, defining the TF mode of interaction and regulatory effect, and the experimental techniques supporting the annotation for each site.