Table 5.
Factors Associated With Clinically Significant AF Episodes Requiring Hospitalization/Medical Intervention During Pregnancy Among Patients With a Pre‐Pregnancy Diagnosis of AF (n=93)
| Parameter | Univariablea | |||
|---|---|---|---|---|
| AF (n=11) | No Recurrent AF (n=82) | Odds Ratio (95% CI) | P Value | |
| Maternal age, y | 31.6±6.0 | 32.8±5.3 | 1.0 (0.9–1.1) | 0.49 |
| White race | 8 | 35 | 3.6 (0.9–14.5) | 0.07 |
| Maternal preconception weight, lbs | 204.7±54.6 | 165.7±44.1 | 1.02 (1.00–1.03) | 0.02 |
| Hypertension (pre‐existing) | 1 | 5 | 1.5 (0.2–14.6) | 0.71 |
| Hyperlipidemia | 2 | 9 | 1.8 (0.3–9.7) | 0.49 |
| Obesity (BMI >30) | 7 | 26 | 3.8 (1.0–14.1) | 0.048 |
| Diabetes (pre‐existing) | 2 | 4 | 4.3 (0.7–27.0) | 0.15 |
| Multigravida (gravida ≥2) | 8 | 64 | 0.8 (0.2–3.1) | 0.69 |
| Obstetric complications | 4 | 9 | 4.4 (1.1–18.2) | 0.04 |
Values are mean±SD or n (%). Obstetric complications: including pregnancy‐induced hypertension, pre‐eclampsia, eclampsia (pre‐eclampsia with grand mal seizures), hemolysis elevated liver enzymes low platelets (HELLP) syndrome, premature rupture of membranes, premature labor, postpartum hemorrhage, or placental abruption. Multivariable model included maternal age, obesity, and obstetric complications. AF indicates atrial fibrillation or atrial flutter; BMI, body mass index; lbs, pounds.
To avoid bias, for patients with multiple pregnancies, only 1 randomly selected pregnancy per patient was included in the logistic regression analysis.