Table 1.
Lipoprotein Subclasses in the LDLR+/+, LDLR+/−, and LDLR−/− Pigs, Shown By Particle Size
| Cholesterol (mg/dL) | Triglyceride (mg/dL) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| LDLR+/+ (n=3) | LDLR+/− (n=8) | LDLR−/− (n=6) | P1 (+/− vs +/+) | P2 (−/− vs +/+) | LDLR+/+ (n=3) | LDLR+/− (n=8) | LDLR−/− (n=6) | P1 (+/− vs +/+) | P2 (−/− vs +/+) | |
| Total | 169.8±12.8 | 158.5±6.5 | 620.3±41.1 | 0.99 | <0.01a | 35.7±5.7 | 26.2±2.1 | 41.0±4.9 | 0.23 | 0.60 |
| CM (>70 nm) | ||||||||||
| G01 (>90 nm) | 0.5±0.1 | 0.4±0.02 | 0.8±0.1 | 0.64 | 0.14 | 4.9±0.7 | 3.8±0.4 | 5.0±1.2 | 0.62 | 0.99 |
| G02 (75 nm) | 0.2±0.04 | 0.1±0.01 | 0.4±0.1 | 0.82 | 0.56 | 1.4±0.2 | 1.2±0.1 | 1.6±0.4 | 0.82 | 0.88 |
| VLDL (30–70 nm) | ||||||||||
| G03 (64 nm) | 0.3±0.1 | 0.2±0.02 | 0.7±0.1 | 0.97 | <0.01a | 1.8±0.1 | 1.5±0.2 | 2.1±0.6 | 0.82 | 0.84 |
| G04 (53.6 nm) | 0.6±0.1 | 0.3±0.1 | 2.9±0.5 | 0.78 | <0.01a | 3.1±0.4 | 2.3±0.3 | 3.4±0.6 | 0.41 | 0.88 |
| G05 (44.5 nm) | 1.2±0.3 | 1.2±0.1 | 13.6±1.2 | 0.99 | <0.01a | 6.2±1.6 | 3.9±0.6 | 5.3±0.6 | 0.14 | 0.68 |
| G06 (36.8 nm) | 2.1±1.1 | 0.8±0.1 | 35.5±4.5 | 0.93 | <0.01a | 4.1±1.7 | 2.1±0.2 | 3.2±0.3 | 0.06 | 0.52 |
| G07 (31.3 nm) | 16.3±3.5 | 13.2±0.8 | 105.0±9.7 | 0.92 | <0.01a | 1.5±0.6 | 0.7±0.1 | 1.5±0.2 | 0.04a | 0.99 |
| LDL (16–30 nm) | ||||||||||
| G08 (28.6 nm) | 32.6±4.5 | 33.1±1.7 | 186.4±12.8 | 0.99 | <0.01a | 3.4±0.9 | 2.1±0.3 | 3.5±0.4 | 0.11 | 0.99 |
| G09 (25.5 nm) | 27.5±2.6 | 33.7±2.7 | 148.4±8.4 | 0.70 | <0.01a | 3.9±0.7 | 3.6±0.3 | 6.6±0.6 | 0.89 | 0.01a |
| G10 (23 nm) | 9.7±0.3 | 13.9±1.5 | 52.1±2.9 | 0.37 | <0.01a | 1.6±0.2 | 2.0±0.2 | 4.2±0.4 | 0.53 | <0.01a |
| G11 (20.7 nm) | 3.3±0.1 | 4.8±0.6 | 18.7±1.1 | 0.37 | <0.01a | 0.5±0.1 | 0.7±0.1 | 1.5±0.1 | 0.55 | <0.01a |
| G12 (18.6 nm) | 1.5±0.2 | 1.4±0.1 | 2.7±0.2 | 0.92 | <0.01a | 0.3±0.01 | 0.3±0.02 | 0.4±0.1 | 0.99 | 0.11 |
| G13 (16.7 nm) | 0.9±0.1 | 1.0±0.1 | 3.8±0.2 | 0.85 | <0.01a | 0.2±0.03 | 0.2±0.01 | 0.3±0.03 | 0.99 | <0.01a |
| HDL (8–16 nm) | ||||||||||
| G14 (15 nm) | 1.3±0.2 | 0.7±0.1 | 1.6±0.1 | 0.03a | 0.21 | 0.2±0.01 | 0.1±0.01 | 0.2±0.03 | 0.95 | 0.88 |
| G15 (13.5 nm) | 0.3±0.2 | 0.5±0.2 | 1.8±0.1 | 0.57 | <0.01a | 0.1±0.01 | 0.1±0.02 | 0.2±0.03 | 0.99 | 0.02a |
| G16 (12.1 nm) | 6.8±2.0 | 2.2±0.6 | 2.7±0.5 | <0.01a | 0.02a | 0.3±0.1 | 0.2±0.01 | 0.2±0.04 | 0.06 | 0.31 |
| G17 (10.9 nm) | 34.6±3.4 | 29.1±1.3 | 22.5±2.0 | 0.14 | <0.01a | 0.7±0.1 | 0.6±0.04 | 0.6±0.1 | 0.69 | 0.70 |
| G18 (9.8 nm) | 14.8±2.2 | 15.8±0.8 | 14.6±0.8 | 0.71 | 0.98 | 0.7±0.3 | 0.3±0.02 | 0.4±0.1 | 0.04a | 0.14 |
| G19 (8.8 nm) | 3.7±0.4 | 4.1±0.2 | 4.2±0.2 | 0.53 | 0.35 | 0.3±0.1 | 0.3±0.02 | 0.3±0.03 | 0.46 | 0.95 |
| G20 (7.6 nm) | 1.8±0.2 | 1.7±0.1 | 2.0±0.1 | 0.93 | 0.23 | 0.6±0.1 | 0.4±0.03 | 0.5±0.04 | 0.02a | 0.14 |
CM indicates chylomicron; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; VLDL, very low‐density lipoprotein.
a
Significant difference.