Table 1.
Characteristics of patients and radiation-induced sarcoma (RIS)
| Characteristic | No. (%) |
|---|---|
| Sex | |
| Male | 8 (24.2) |
| Female | 25 (75.8) |
| Age at primary radiotherapy, median (range, yr) | 44 (0-71) |
| 0-19 | 3 (9.1) |
| 20-39 | 6 (18.2) |
| 40-59 | 20 (60.6) |
| ≥ 60 | 4 (12.1) |
| Age at diagnosis of RIS, median (range, yr) | 55 (22-85) |
| Latency, median (range, yr) | 12.1 (1.9-28.8) |
| Primary tumor | |
| Breast ca. | 9 (27.3) |
| Cervical ca. | 8 (24.2) |
| Rectal ca. | 5 (15.2) |
| Head and neck ca. | 7 (21.2) |
| Retinoblastoma | 1 (3.0) |
| Craniopharyngioma | 1 (3.0) |
| Lymphoma (DLBC, spine) | 1 (3.0) |
| Wilms' tumor | 1 (3.0) |
| Radiation dose (Gy) | |
| < 20 | 1 (3.0) |
| 20-40 | 2 (6.0) |
| 40-60 | 17 (51.5) |
| ≥ 60a) | 13 (39.4) |
| Chemotherapy for primary cancer | |
| Yes | 21 (63.3) |
| No | 12 (36.7) |
| RIS location | |
| Trunk | 25 (75.8) |
| Head and neck | 8 (24.2) |
| RIS histology | |
| Osteosarcoma | 12 (36.4) |
| MFH | 11 (33.3) |
| Angiosarcoma | 2 (6.1) |
| Chondrosarcoma | 1 (3.0) |
| Endometrial stromal sarcoma | 1 (3.0) |
| Low-grade fibromyxoid sarcoma | 1 (3.0) |
| Myxofibrosarcoma | 1 (3.0) |
| Myxoid liposarcoma | 1 (3.0) |
| Undifferentiated sarcoma | 1 (3.0) |
| Sarcoma unspecified | 1 (3.0) |
| Tumor size, median (range, cm) | 4.8 (1.5-12.5) |
| Tumor depth | |
| Deep | 27 (81.8) |
| Superficial | 6 (18.2) |
RIS, radiation induced sarcoma; DLBC, diffuse large B cell; MFH, malignant histiocytoma.
a)
Four patients received intracavitary brachytherapy in addition to external-beam radiation therapy for treatment of cervical cancer.