Table 3.
Multivariate Cox regression analysis of predictors for conditional 5-year overall survival from baseline to 5 years after surgery
| Variable | Hazard ratio (95% confidence interval) |
|||||
|---|---|---|---|---|---|---|
| Baseline | 1 yr | 2 yr | 3 yr | 4 yr | 5 yr | |
| Age (≥ 65 vs. < 65) | 2.87 (1.93-4.26) | 2.71 (1.78-4.13) | 2.67 (1.69-4.21) | 2.72 (1.58-4.66) | 3.05 (1.61-5.79) | 5.31 (2.01-13.97) |
| p-value | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.001 | 0.001 |
| Bladder cancer history (positive vs. negative) | - | 1.63 (1.02-2.61) | - | - | - | - |
| p-value | - | 0.043 | - | - | - | - |
| Location (vs. pelvis) | ||||||
| Ureter | 1.05 (0.67-1.63) | - | 1.13 (0.67-1.87) | 1.15 (0.62-2.13) | - | 1.53 (0.56-4.15) |
| Both | 1.86 (1.13-3.06) | - | 1.99 (1.11-3.56) | 2.74 (1.39-5.36) | - | 5.45 (1.99-14.89) |
| p-value | 0.015 | - | 0.020 | 0.003 | - | 0.001 |
| pT stage (≥ 3 vs. ≤ 2) | 2.02 (1.32-3.08) | 2.17 (1.41-3.34) | 1.93 (1.18-3.15) | - | - | - |
| p-value | 0.001 | < 0.001 | 0.008 | - | - | - |
| Grade (high vs. low) | 1.69 (1.01-2.84) | 2.09 (1.21-3.61) | 2.23 (1.26-3.97) | 3.41 (1.74-6.67) | 2.54 (1.24-5.21) | - |
| p-value | 0.045 | 0.008 | 0.006 | < 0.001 | 0.011 | - |
| LVI (yes vs. no) | 2.17 (1.42-3.30) | 2.05 (1.28-3.28) | - | - | - | - |
| p-value | < 0.001 | 0.003 | - | - | - | - |
| Margin (positive vs. negative) | 2.21 (1.19-4.07) | 2.17 (1.08-4.33) | - | - | - | - |
| p-value | 0.011 | 0.029 | - | - | - | - |
LVI, lymphovascular invasion.