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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Feb 4;55(10):3398–3402. doi: 10.1002/anie.201510972

Figure 2.

Figure 2

Mechanistic investigations of the conjugate addition/asymmetric protonation/aza-Prins cyclization. Standard conditions: 7c (1.0 equiv), Z-2a-d (1.0 equiv), (R)-3,3’-dibromo-BINOL (20 mol %), ZrCl4 (1.6 equiv), 2,6-dibromophenol (1.0 equiv), TMSCl (1.0 equiv), CH2Cl2, 23 °C.