FIGURE 4.

Quantification of the anti-influenza IFNγ response by ELISPOT assays on day 0 and days 7 or 14 post-influenza vaccination. Both controls (A; N=21) and transplant patients (B; N=17) had a significant response to influenza vaccine; however, the magnitude of the response was significantly decreased in transplant recipients (C). Data are presented as medians and statistical significance was determined by Wilcoxon paired rank test (A and B) and Mann-Whitney test (C). Statistically significant correlation between the influenza-specific IFNγ and IgG response (measured by ELISPOT) in healthy controls (right), but no significant correlation in transplant recipients (left).