Table 3.

Relevant assays for comprehensive phenotyping of mouse models of Alzheimer’s disease

Behavioral Domain	Assay
Motor, Coordination, & Strength	Locomotor Activity – Open Field
	Gait - Treadmill or spontaneous walking
	Coordination – accelerating rotarod
	Strength – grip strength
Cognition	Learning & Memory – Water Maze
	Learning & Memory – Contextual Fear Conditioning
	Learning & Memory - Visual Discrimination & Reversal Task (Touchscreen)
	Learning & Memory- Paired Associates Learning Task (Touchscreen)
	Learning & Memory – Baited Holeboard Task
	Memory – Novel Object or Novel Spatial Recognition Task
	Spatial Working Memory – Spontaneous Alternation
	Episodic Memory - Episodic Memory Task
	Attention – 5 Choice Serial Reaction Time Task
Disease Progression	Vision- electroretinography
	Visual acuity – optokinetics
	Hearing – Auditory Brainstem Responding
	Hearing – Acoustic Startle Response
	Fine Motor – adhesive removal test
	Metabolism – Indirect Calorimetry
	Blood Pressure Monitoring
	Bone Densitometry (DEXAscan)
Co-morbidity Phenotypes	Anxiety – Light/Dark Test
	Anxiety - Stress-Induced Hyperthermia Assay
	Anxiety – Elevated Zero or Plus Maze
	Depression – Forced Swim Test
	Depression – Tail Suspension Test
	Social Behavior
	Motivation – Progressive Ratio Responding
	Motivation – sexual behavior
	Circadian Activity– Wheel Running
	Sleep - EEG