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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Hepatol. 2015 Aug 5;64(1):60–68. doi: 10.1016/j.jhep.2015.07.030

Fig. 2. Hepatocyte-derived exosomes induce hepatocyte proliferation in vitro.

Fig. 2

Exosomes isolated from primary hepatocytes (A), Kupffer cells (B), or sinusoidal endothelial cells (C), were added to primary hepatocytes and proliferation measured 24 h later by BrdU incorporation. Exosomes from primary hepatocytes dose-dependently increased hepatocyte proliferation. Kupffer cell exosomes reduced hepatocyte proliferation and exosomes from sinusoidal endothelial cells had no effect on proliferation. For all panels, data are mean ± SD with n = 8 (A, B) or n = 6–8 (C) per group. *p <0.05 compared to media control (0 exosomes), #p <0.05 compared to all other groups.