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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Hepatol. 2015 Aug 5;64(1):60–68. doi: 10.1016/j.jhep.2015.07.030

Fig. 6. SK2 mediates the proliferative effects of hepatocyte exosomes.

Fig. 6

(A) Transfection of hepatocytes with siRNA targeting SK2 downregulates SK2 expression, while a control scrambled (scr) siRNA has no effect. Shown are Western blot studies representative of three independent experiments. (B) Exosomes derived from hepatocytes in which SK2 had been knocked down or SK2-knockout (KO) hepatocytes have no proliferative effect on target hepatocytes in vitro. (C) Biochemical inhibition of SK with FSBA prevents the proliferative effects of exosomes on hepatocytes. For all panels, data are the mean ± SD with n = 4; *p <0.05 compared to control group; #p <0.05 compared to scr siRNA group.