Fig. 2.

Illustrative time courses of change in outer diameter measured with the video microscope ($d_{\mathrm{o}}$—top panels), axial force measured by the force transducer ($f_{\mathrm{T}}$—middle panels), and wall thickness measured with the OCT (h—bottom panels), all when contracted with 80 mM KCl at 90 mmHg for Fbln5^+/+ (left) and Fbln5^−/− (right) DTAs at genotype-specific values of axial stretch: ${\lambda }_{\mathrm{z}}=1.40, 1.50, \text{and}\hspace{0.17em}1.60$ for Fbln5^+/+ and ${\lambda }_{\mathrm{z}}=1.25, 1.30, \text{and}\hspace{0.17em}1.35$ for Fbln5^−/−. Recall that contraction was maintained at each condition for ∼15 min prior to a wash-out with normal Krebs solution. The vertical dashed lines delineate changes in the different fixed values of axial stretch; the dark dashed arrows illustrate, for a single case, the magnitude and direction of contraction-induced changes in outer diameter and axial force that are considered in Fig. 3.