Table 1.
Drosophila TRP channels with thermosensory functions
| Channel | Group | Activation mechanisms | Thermosensory function |
|---|---|---|---|
| dTRPA1 | TRPA | Reactive electrophiles48 | Detection of temperature fluctuations |
| Heat (>26°C for A isoform; within the comfortable range72,80 | |||
| >34°C for D isoform)34,50,51 | Thermotaxis response to elevated temperature44 | ||
| Gαq-PLC signaling46,49,72 | Noxious heat avoidance50,150 | ||
| Synchronization of circadian rhythms to temperature cycles141,142 | |||
| Painless | TRPA | Heat32 | Noxious heat avoidance18 |
| Pyrexia | TRPA | Heat33 | Synchronization of circadian rhythms to temperature cycles60 |
| Noxious heat resistance33 | |||
| TRP | TRPC | Gαq-PLC signaling66 | Thermotaxis responses to cool temperatures36 |
| Polyunsaturated fatty acids155 | |||
| Mechanical force156 | |||
| TRPL | TRPC | Gαq-PLC signaling67 | Thermotaxis responses to cool temperatures36 |
| Polyunsaturated fatty acids155 | |||
| Mechanical force156 | |||
| Inactive | TRPV | Osmotic stimulation82 | Thermotaxis responses to cool temperatures35 |
| Brivido-1 | TRPP (non-channel) | — | Thermotaxis responses to cool temperatures37 |
| Brivido-2 | TRPP (non-channel) | — | Thermotaxis responses to cool temperatures37 |
| Brivido-3 | TRPP (non-channel) | — | Thermotaxis responses to cool temperatures37 |