. 2015 Feb 25;2(2):172–177. doi: 10.1080/23328940.2015.1012979

Table 1.

Relation between TRP ion channels, airway symptoms and temperature

TRP ion channels	Airway symptoms	Temperature °C	Related stimuli
TRPV1	Cough, rhinitis and dyspnea induced from “noxious” stimuli	≥42°	Capsaicin
			pH ≤ 5.9
			“Noxious” stimuli
			Ethanol
			Vanilloides
			Pain
TRPV3 TRPV4	Asthma, cough, dry eyes	22–40°	Osmolarity Mechanical stimuli
TRPM8 TRPM4	Inhalation of menthol reduces cough	8–22°	“Cool” stimuli
TRPM8 TRPM4	Inhalation of menthol reduces cough	8–22°	Menthol
TRPA1	Asthma, cough, laryngeal obstruction, rhinitis	<8° and below	Mustard oil
			Garlic
			“Noxious” stimuli?
			Pain