Table 3.

The latency of the emetic response to vanilloids/capsiacinoids given subcutaneously (s.c.) or intracerebroventricularly (i.c.v.). Note that there is relatively little difference between the latency irrespective of substance or route

Substance	Route	Dose	Species	Latency for emesis ± sem	Reference
RTX	s.c.	1000 μg/kg	Suncus murinus	2.7 ± 0.6 min	68
RTX	s.c.	100 nmol/kg	Suncus murinus	8.2 ± 1.3 min	70
RTX	i.a.	40 nmol/kg	Suncus murinus	1.7 ± 0.6 min	79
RTX	s.c.	18 μg/kg	Cryptotis parva	∼10 min	74
capsaicin	s.c.	100–300 μmol/kg	Suncus murinus	∼10min	Wan, Rudd, Chu, Ngan and Wai, 2008, unpublished observations
olvanil	s.c.	3–30 μmol/kg	Suncus murinus	∼30min	Wan, Rudd, Chu, Ngan and Wai, 2008, unpublished observations
RTX	i.c.v.	6 μg	Suncus murinus	1.4 ± 0.3 min	68
RTX	i.c.v.	30 nmol	Suncus murinus	5.7 ± 1.4 min	69
E-capsaicin	i.c.v.	10 nmol	Suncus murinus	0.9 ± 1.5 min	69
Z-capsaicin	i.c.v.	100 nmol	Suncus murinus	4.5 ± 1.8 min	69
capsaicin	IV ventricle	33 mM	dog	3–5.5 min	72