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The divergent thermal sensitivity of TRPA1 channels. TRPA1 is heat-sensitive in invertebrate and ancestral vertebrate (e.g., rattle snake), cold-sensitive in rodents (e.g., rat) and temperature-insensitive in primates (e.g., human). A Glycine (G) residue is critical for cold-activation of rodent TRPA1, whereas an equivalent Valine (V) residue is preserved in other species.
