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. 2015 Jul 28;2(3):392–405. doi: 10.1080/23328940.2015.1069437

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 13. — Intravenous administration of 5-hydroxytryptamine (5HT) 1A receptor agonist (8-OH-DPAT) inhibits cold-induced ear pinna cutaneous vasoconstriction in conscious rabbits. Microinjection of 5-HT1A receptor antagonist (WAY-100635), into the medullary raphé/parapyramidal region reverses the ear pinna cutaneous vasomotor response to intravenous administration of 8-OH-DPAT. Records of ultrasonic Doppler signal measuring phasic ear pinna blood flow in conscious freely moving rabbits. Modified from Ootsuka and Blessing.¹⁰¹ © Elsevier. Permission to reuse must be obtained from the rightsholder. The second intravenous injection of 8-OH-DPAT after the WAY-100635 did not cause significant effect on cutaneous blood flow, confirming antagonize action of WAY-100635 on 8-OH-DPAT.