Table 2.

Number of genes interacting with cdc13‐1 at $27{}^{\circ }$C identified by using each of four approaches: Addinall et al. (2011) and the REM, IHM and JHM^a

Method	Suppressors	Enhancers	Hits	Suppressors (half‐data)	Enhancers (half‐data)	Hits (half‐data)	Telomere maintenance (N=33)	p‐value	q‐value	Aging (N=58)	p‐value	q‐value	Response to DNA damage stimulus (N=58)	p‐value	q‐value	Peroxisome organization (N=180)	p‐value	q‐value
Addinall et al. (2011)	419	296	715	263	192	455	18	$1.52\times {10}^{-6}$	0.0376	16	$4.32\times {10}^{-5}$	0.1863	69	$9.28\times {10}^{-12}$	$8.14\times {10}^{-10}$	13	0.225	0.468
REM	184	131	315	103	86	189	11	$2.37\times {10}^{-5}$	0.0136	10	0.0004	0.0824	49	$7.40\times {10}^{-16}$	$1.73\times {10}^{-13}$	3	0.855	0.914
IHM	404	172	576	252	113	365	14	$6.57\times {10}^{-5}$	0.0051	16	0.0015	0.0445	55	$4.60\times {10}^{-9}$	$3.41\times {10}^{-7}$	10	0.318	0.524
JHM	665	274	939	475	177	601	18	$8.22\times {10}^{-5}$	0.0155	21	0.0015	0.0986	76	$3.52\times {10}^{-9}$	$1.99\times {10}^{-7}$	24	0.002	0.019

^aNumber of genes classified (or annotated) with four example gene ontology terms (telomere maintenance, aging, response to DNA damage stimulus and peroxisome organization) are also listed. For the approach of Addinall et al. (2011) and REM, significant interactors are classified as those with false discovery rate corrected p‐values (or q‐values) less than 0.05. The label ‘half‐data’ denotes analyses where only half of the available experimental observations are used.