TABLE 1.
Clinical Trial Studies Reviewed
| Study | No. of patients |
Activity (MBq) | Extent of scan | Technique | Mean age (y) | Sex |
|---|---|---|---|---|---|---|
| Emory initial pilot | 18 | 292.3 (99.9) | Skull vertex to thighs |
60-min dynamic brain (followed by whole-body imaging) |
53.8 (9.3) | Male, 12; female, 6 |
| Emory dosimetry | 6 | 366.6 (51.0) | Skull vertex to thighs |
6 sets of serial static scans for 120 min |
48 (15.0) | Male, 3; female, 3 |
| Emory prostate pilot | 15 | 372.6 (22.9) | Abdomen/pelvis | 65-min dynamic pelvis (followed by abdomen/pelvis) |
62.0 (8.8) | Male, 15 |
| Emory renal pilot | 6 | 388.5 (14.1) | Abdomen | 120-min dynamic renal-level abdomen |
67.3 (15.1) | Male, 5; female, 1 |
| Emory lung pilot | 10 | 313.5 (76.7) | Chest | 45-min dynamic lesion-level chest |
66.4 (12.8) | Male, 3; female, 7 |
| Emory recurrent prostate cancer |
128 scans in 115 patients |
358.9 (51.8) | Abdomen/pelvis | 60-min sequential multiphase abdomen/pelvis |
67.3 (7.6) | Male, 128 |
| Emory primary prostate cancer |
11 | 347.8 (81.4) | Pelvis | 60-min dynamic pelvis | 60.8 (6.3) | Male, 11 |
| Emory breast pilot | 3 | 360.0 (14.1) | Chest | 45-min dynamic breast level |
60 (8.9) | Female, 3 |
| Emory parathyroid | 3 | 351.5 (34.0) | Neck | 60-min sequential multiphase neck/upper chest |
60.3 (6.4) | Male, 1; female, 2 |
| Emory recurrent prostate cancer outcomes |
13 | 367.0 (15.5) | Abdomen/pelvis | 30-min sequential multiphase abdomen/pelvis |
61.5 (9.2) | Male, 13 |
| Emory PET and MR recurrent prostate cancer |
6 | 373.7 (9.4) | Abdomen/pelvis | 30-min sequential multiphase abdomen/pelvis |
69 (5.1) | Male, 6 |
| Bologna recurrent prostate cancer |
61 | 379 (12.1) | Skull vertex to thighs |
Single static scan starting at thighs |
67.8 (6.5) | Male, 61 |
| Kitasato phase one dosimetry |
6 | 195.0 (10.3) | Skull vertex to thighs |
11 series of whole-body PET scans during 3 sessions of 0–90, 150–170, and 220–240 min |
24 (3.0) | Male, 6 |
| Uppsala phase one primary prostate cancer |
6 | 418 (10.0) | Pelvis | 90 (optional 120)-min dynamic pelvis |
67 (5.0) | Male, 6 |
| NIH primary prostate cancer |
21 | 351.5 (9.0) | Pelvis/lower abdomen dynamic, whole-body static at end |
30-min dynamic pelvis, then 10-min dynamic lower abdomen (followed by static whole body) |
62 (6.5) | Male, 21 |
| Oslo University Hospital prostate and other cancers |
298 | 296 (56.0) | Skull vertex to thighs |
Single static scan starting at thighs |
66.0 (6.4) | Male, 297; female, 1 |
Data in parentheses are SDs.