FIGURE 6. Dose–response curves and time to maximal effect of rocuronium in adult burned and non-burned patients.

Dose versus time to percent twitch suppression for rocuronium in control subjects and burned subjects of mean 40% total body surface area (TBSA) burn and studied at least one week after burn. In normal patients dose of 0.9 mg/kg rocuronium caused 95% twitch suppression in ≤60 s. The same dose has an onset of >120 s following major burn. Increasing doses of rocuronium shifted dose-response curves to the left. However, even with 1.5 mg/kg dose, the onset was still >90 s. TOF Ratio refers to train-of-four ratio recorded in muscle during 2Hz nerve stimulation.^{64, 104}