Table 8.1.
Examples of GPCR Heterocomplexes with potential roles in neuropsychiatric disorders
| GPCR heterocomplex |
Experimental approaches | Neuropsychiatric relevance |
|---|---|---|
| A1–A2A | Cell lines, striatum (IP, BRET, FRET) |
Drug tolerance |
| A1–D1 | Cell lines, striatum (IP, BRET, BP) |
Involved in PD and cocaine addiction |
| A1–mGlu1 | Cell lines (IP) | Involved in schizophrenia |
| A1–5HT2A | Cortex (BP) | Involved in schizophrenia |
| A2A–D2 | Cell lines, striatum (IP, BRET, FRET, Phar, BP) |
Reversal of PD deficits, putative antipsychotic, and anticocaine properties |
| A2A–mGlu5 | Cell lines, striatum (IP) | Possible PD, schizophrenia, and cocaine treatment |
| A2A–D2– mGlu5 |
Cell lines, striatum (IP, SRET) |
Possible PD, schizophrenia, and cocaine treatment |
| A2A–CB1 | Cell lines, striatum (IP, BRET, BP) |
|
| A2A–CB1–D2 | Cell lines (BP, SRET) | Involved in schizophrenia |
| α2A–MOR | Cell lines, striatum (IP, BRET, FRET) |
Involved in addiction |
| CB1–D2 | Cell lines, striatum (IP, FRET, Phar, BP) |
Possible PD, addiction, and schizophrenia treatment |
| CRH1–V1b | Cell lines (IP, BRET, FRET) |
Involved in mood disorder, depression |
| D1–D2 | Cell lines, striatum (IP, FRET) |
Possible PD, schizophrenia, and treatment |
| D1–D3 | Cell lines (BRET, FRET, Phar, BP) |
Cocaine addiction |
| D2–D3 | Cell lines, striatum (IP, BP) | Involved in PD and schizophrenia |
| D2–H3 | Cell lines, striatum (BRET, Phar, BP) |
Involved in PD |
| D4–MOR | Striatum (Phar) | Acquisition during drug addiction and risks for drug use initiation |
| mGlu2–5HT2A | Cell lines, cortex (IP, BRET, FRET, Phar, BP) |
Possible schizophrenia treatment |
IP, coimmunoprecipitation; BRET, bioluminescence resonance energy transfer; FRET, fluorescence resonance energy transfer; SRET, sequential resonance energy transfer; Phar, pharmacological allosteric effects in radioligand binding assays; PD, Parkinson’s disease; BP, behavioral paradigms.