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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Gastroenterology. 2016 Feb 2;150(5):1219–1230.e6. doi: 10.1053/j.gastro.2016.01.032

Fig.2.

Fig.2

In the Liver Biopsy cross-sectional Cohort, the MBOAT7/TMC4 rs641738 variant is associated with the severity of histological damage. The histological damage was evaluated by the different components of NAFLD activity score (NAS) and with hepatic fibrosis stage. CC: homozygotes for the C allele; CT: heterozygotes; TT: homozygotes for the T allele. The association between the MBOAT7/TMC4 rs641738 variant and the components of the NAS has been tested by multivariate ordinal regression analysis adjusted for age, gender, BMI, presence of IFG/T2DM, number of PNPLA3 I148M alleles, presence of the TM6SF2 E167K variant, and indication of liver biopsy (severe obesity vs. nonalcoholic fatty liver with increased liver enzymes). Genetic analyses were calculated by using an additive model, except for TM6SF2 where a dominant model was used due to few homozygotes for the 167K mutant allele. P-values represent the significance of a trend in the prevalence of more severe degree of histological damage among genotypes.