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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Gastroenterology. 2016 Feb 2;150(5):1219–1230.e6. doi: 10.1053/j.gastro.2016.01.032

Fig.3.

Fig.3

MBOAT7 but not TMC4 is highly expressed in human liver and the rs641738 variant is associated with lower circulating levels of Phosphatidylinositol 36:4/34:2 ratio. (A) Distribution of MBOAT7 and TMC4 mRNA in 14 human tissues. (B) MBOAT7 and TMC4 mRNA expression in human primary hepatic cell types. Gene expression level was assessed by qPCR. The tissue or the cell line with the highest CT value was assigned the value of 1. (C) Ratio of phosphatidylinositol species containing different degree of saturation stratified by the rs643718 C>T genotype in the combined Dallas Heart Study (DHS) cohort and stratified by the three ethnic groups composing the study.

Abbreviations: MBOAT7, Membrane Bound O-Acyltransferase domain containing 7; TMC4, Transmembrane Channel-like 4; HH, Human Hepatocytes; HSC, Hepatic Stellate Cells; HHSEC, Human Hepatic Sinusoidal Endothelial Cell.