Table 3. Polymorphism of CT60 (rs3087243) of the CTLA4 gene in adult Graves disease, pediatric Graves disease, Hashimoto disease patients and controls.
| Adult Graves disease | Pediatric Graves disease | Pediatric Hashimoto disease | Controls | ||||
|---|---|---|---|---|---|---|---|
| N = 289 | N = 265 | N = 229 | N = 1058 | ||||
| Genotype | N(%) | OR(95%CI) | N(%) | OR(95%CI) | N(%) | OR(95%CI) | N(%) |
| A/A | 3(1.0) | 0.23(0.07–0.75) | 7(2.6) | 0.60(0.27–1.34) | 7(3.1) | 0.69(0.31–1.56) | 46 (4.3) |
| A/G | 81(28.0) | 0.69(0.52–0.92) | 68(25.7) | 0.61*(0.45–0.83) | 67(29.3) | 0.76(0.56–1.05) | 382(36.1) |
| G/G | 205(70.9) | 1.66**(1.25–2.20) | 190(71.7) | 1.72**(1.28–2.31) | 155(67.7) | 1.42(1.05–1.93) | 630(59.5) |
| Allele | |||||||
| A | 87(15.1) | 0.61**(0.48–0.79) | 82(15.5) | 0.63**(0.49–0.82) | 81(17.7) | 0.74(0.57–0.97) | 474(22.4) |
| G | 49 (84.9) | 1.63**(1.27–2.09) | 448(84.5) | 1.58**(1.22–2.04) | 377(82.3) | 1.34(1.04–1.74) | 1642(77.6) |
| Carrier | |||||||
| A | 84(29.1) | 0.60**(0.45–0.80) | 75(28.3) | 0.58**(0.43–0.78) | 74(32.3) | 0.70(0.52–0.95) | 428(40.5) |
| G | 286(99.0) | 4.33(1.34–14.04) | 258(97.4) | 1.68(0.75–3.75) | 222(96.9) | 1.44(0.64–3.24) | 1012(95.7) |
Significant values are in bold (Pc <0.05).
* Pc <0.01.
**Pc <0.001.
Hardy-Weinberg test for adult GD: χ2 = 2.66, P = 0.26; pediatric GD: χ2 = 0.10, P = 0.95; pediatric HD: χ2 = 0.01, P = 1.0; controls: χ2 = 1.57, P = 0.46.