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. 2016 Apr 25;11(4):e0152073. doi: 10.1371/journal.pone.0152073

Fig 1. CD200 is constitutively released from CLL cells.

Fig 1

a) CLL cells (n = 3) were treated with 450nM of TIMP1, TIMP2, and TIMP3, and TIMP4, and supernatants collected at 48hr. % inhibition of CD200 shedding was calculated with reference to sCD200 levels in supernatants from untreated control cells (varying from 0.1–0.3ng/ml in individual patients). b) CLL plasma was depleted of exosomes/microvesicles using the methodology described. All studies were repeated with three different CLL plasma samples. Data from a representative experiment is shown.