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. 2015 Oct 27;10(12):1111–1120. doi: 10.1080/15592294.2015.1110672

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Figure 3. — Histological thymic alterations in KM mice. (A) The cortex is expanded by a heterogeneous (hyperplastic) lymphoid cell population, with retention of the normal thymic architecture in a 1-month-old KM mouse. (B) The architecture of the hyperplastic thymus in a 1-month-old KM mouse is maintained, with the majority of CD3 immunopositive cells in the cortex. (C) The normal architecture of the thymus is completely effaced by a lymphoid round cell neoplasm in a 2.5-month-old KM mouse. (D) Neoplastic lymphoid cells effacing the thymus in a 2.5-month-old KM mouse are diffusely CD3 immunopositive, consistent with T-cell origin of the neoplasm. (E-G) H&E staining of nearby tissues. (E) Neoplastic cells invade adjacent adipose tissue. (F) Neoplastic cells encircling ganglia. (H) Neoplastic cells invade the myocardium at the base of the heart (G) Neoplastic cells invade the musculature of the sternum. All insets show to neoplastic cells at 400X.