Table 2.

Summary of location and enrichment of cell subset- and sex-specific DMGs

DMRs		Promoter	Gene body	Enhancer	CGIs	Open sea
Immune cell subset-specific	DMRs	16% versus 25% of total CpG sites (reduced)	42% versus 33% of total CpG sites (enriched)	75% versus 64% of total CpG sites (enriched)	7% versus 31% of total CpG sites (reduced)	55% versus 36% of total CpG sites (enriched)
	% DMGs of negatively correlated DEG-DMG pairs	27%	47%
	% DMGs of positively correlated DEG-DMG pairs	12%	70%
Sex-specific	DMGs	20% versus 25% of total CpG sites (reduced)	36% versus 33% of total CpG sites (no change)	60% versus 64% of total CpG sites (no change)	38% versus 31% of total CpG sites (enriched)	31% versus 36% of total CpG sites (reduced)

Percentage of DMGs in a specific location, compared to the total CpG sites scanned by the chip in the location. We defined a difference ≥ 5% as enrichment or reduction.

Percentage of DMGs in the promoter or gene body out of correlated DEG-DMG pairs (other locations not included)