Table 1.
Hypermethylated genes on 3p11.2-p14.2 in cervical cancer
| Gene symbola | Gene name | Hypermethylation frequency (%)b | Regulation patternc |
|---|---|---|---|
| FHIT | Fragile histidine triad | 18.5 | Combined |
| C3orf14 | Chromosome 3 open reading frame 14 | 48.6 | Methylation |
| FEZF2 | FEZ family zinc finger 2 | 81.4 | ND |
| CADPS | Ca2+-dependent secretion activator | 78.4 | ND |
| SYNPR | Synaptoporin | 74.8 | ND |
| THOC7 | THO complex 7 homolog (Drosophila) | 55.0 | Gene dosage |
| ATXN7 | Ataxin 7 | 55.0 | ND |
| PSMD6 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 46.3 | Gene dosage |
| PRICKLE2 | Prickle homolog 2 (Drosophila) | 26.7 | ND |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 63.6 | Combined |
| MAGI1 | Membrane associated guanylate kinase, WW and PDZ domain containing 1 | 51.0 | ND |
| LRIG1 | Leucine-rich repeats and immunoglobulin-like domains 1 | 63.1 | Combined |
| FAM19A1 | Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 | 23.5 | ND |
| FAM19A4 | Family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 | 82.4 | ND |
| MITF | Microphthalmia-associated transcription factor | 16.6 | ND |
| FOXP1 | Forkhead box P1 | 45.2 | ND |
| EIF4E3 | Eukaryotic translation initiation factor 4E family member 3 | 15.4 | ND |
| GPR27 | G protein-coupled receptor 27 | 16.8 | Methylation |
| PROK2 | Prokineticin 2 | 57.9 | ND |
| PPP4R2 | Protein phosphatase 4, regulatory subunit 2 | 20.8 | ND |
| PDZRN3 | PDZ domain containing ring finger 3 | 70.0 | ND |
| ZNF717 | Zinc finger protein 717 | 69.4 | Methylation |
| ROBO2 | Roundabout, axon guidance receptor, homolog 2 (Drosophila) | 81.2 | ND |
| ROBO1 | Roundabout, axon guidance receptor, homolog 1 (Drosophila) | 89.3 | ND |
| GBE1 | Glucan (1,4-α-), branching enzyme 1 | 47.7 | ND |
| CADM2 | Cell adhesion molecule 2 | 79.0 | ND |
a
Genes are listed by chromosomal location.
b
Based on cohort 1of 149 patients.
c
Combined, combined methylation and gene dosage driven regulation; Methylation, methylation driven regulation; Gene dosage, gene dosage driven regulation; ND, none detected.