Table 3a.
Regression of M-Value on Childhood SES in Stress Pathway Genes (n = 1,231)
| Stress Pathway |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
AVP |
BDNF |
FKBP5 |
OXTR* |
|||||||||
| Beta | SE | P-value | Beta | SE | P-value | Beta | SE | P-value | Beta | SE | P-value | |
| Low Childhood SES | −0.017 | 0.007 | 0.020 | 0.006 | 0.004 | 0.148 | −0.001 | 0.004 | 0.877 | 0.025 | 0.010 | 0.015 |
| Promoter | 1.263 | 0.004 | <0.0001 | −2.602 | 0.003 | <0.0001 | −0.211 | 0.004 | <0.0001 | — | — | — |
| Shore/Shelf | 3.040 | 0.010 | <0.0001 | −0.926 | 0.003 | <0.0001 | 0.230 | 0.004 | <0.0001 | 3.315 | 0.016 | <0.0001 |
| SES*Promoter | −0.022 | 0.006 | 0.0002 | −0.009 | 0.004 | 0.020 | −0.014 | 0.006 | 0.020 | — | — | — |
| SES*Shore/Shelf | 0.052 | 0.014 | 0.0002 | −0.003 | 0.004 | 0.419 | 0.017 | 0.006 | 0.007 | −0.047 | 0.022 | 0.033 |
*
For OXTR, all non-shore/shelf sites are also non-promoter sites, and all shore/shelf sites are also promoter sites.
Note: Models control for age, sex, race/ethnicity, and enrichment scores for each of 4 major blood cell types (neutrophils, B cells, T cells, and natural killer cells). Low childhood SES is a dichotomous variable, where 1 = mom < high school.