Table 3b.
Regression of M-Value on Childhood SES in Inflammation Pathway Genes (n = 1,231)
| Inflammation Pathway |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
|
CCL1 |
CD1D |
F8 |
|||||||
| Beta | SE | P-value | Beta | SE | P-value | Beta | SE | P-value | |
| Low Childhood SES | −0.028 | 0.013 | 0.037 | 0.0005 | 0.005 | 0.924 | 0.048 | 0.031 | 0.122 |
| Promoter | −1.710 | 0.011 | <0.0001 | −2.678 | 0.010 | <0.0001 | −1.704 | 0.011 | <0.0001 |
| Shore/Shelf | — | — | — | 4.653 | 0.006 | <0.0001 | 1.401 | 0.035 | <0.0001 |
| SES*Promoter | 0.052 | 0.016 | 0.0009 | 0.048 | 0.015 | 0.0017 | 0.033 | 0.015 | 0.027 |
| SES*Shore/Shelf | — | — | — | −0.006 | 0.008 | 0.463 | −0.087 | 0.048 | 0.069 |
Note: Models control for age, sex, race/ethnicity, and enrichment scores for each of 4 major blood cell types (neutrophils, B cells, T cells, and natural killer cells). Low childhood SES is a dichotomous variable, where 1 = mom < high school.